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Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF). Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by sensory neurons that release substance P (SubP). CFTR is an anion channel involved in fluid secretion and mutated in...

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Bibliografiske detaljer
Main Authors: Choi, Jae Young, Khansaheb, Monal, Joo, Nam Soo, Krouse, Mauri E., Robbins, Robert C., Weill, David, Wine, Jeffrey J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673871/
https://ncbi.nlm.nih.gov/pubmed/19381016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37284
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