Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF). Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by sensory neurons that release substance P (SubP). CFTR is an anion channel involved in fluid secretion and mutated in...

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Detalhes bibliográficos
Main Authors: Choi, Jae Young, Khansaheb, Monal, Joo, Nam Soo, Krouse, Mauri E., Robbins, Robert C., Weill, David, Wine, Jeffrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673871/
https://ncbi.nlm.nih.gov/pubmed/19381016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37284
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