Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal surfaces. However, most promising ARV entry inhibitors are biologicals, which are costly to manufacture and deliver to...

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Bibliographic Details
Main Authors: O'Keefe, Barry R., Vojdani, Fakhrieh, Buffa, Viviana, Shattock, Robin J., Montefiori, David C., Bakke, James, Mirsalis, Jon, d'Andrea, Anna-Lisa, Hume, Steven D., Bratcher, Barry, Saucedo, Carrie J., McMahon, James B., Pogue, Gregory P., Palmer, Kenneth E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662964/
https://ncbi.nlm.nih.gov/pubmed/19332801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901506106
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