Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal surfaces. However, most promising ARV entry inhibitors are biologicals, which are costly to manufacture and deliver to...

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Detalhes bibliográficos
Main Authors: O'Keefe, Barry R., Vojdani, Fakhrieh, Buffa, Viviana, Shattock, Robin J., Montefiori, David C., Bakke, James, Mirsalis, Jon, d'Andrea, Anna-Lisa, Hume, Steven D., Bratcher, Barry, Saucedo, Carrie J., McMahon, James B., Pogue, Gregory P., Palmer, Kenneth E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662964/
https://ncbi.nlm.nih.gov/pubmed/19332801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901506106
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