Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal surfaces. However, most promising ARV entry inhibitors are biologicals, which are costly to manufacture and deliver to...

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Main Authors: O'Keefe, Barry R., Vojdani, Fakhrieh, Buffa, Viviana, Shattock, Robin J., Montefiori, David C., Bakke, James, Mirsalis, Jon, d'Andrea, Anna-Lisa, Hume, Steven D., Bratcher, Barry, Saucedo, Carrie J., McMahon, James B., Pogue, Gregory P., Palmer, Kenneth E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662964/
https://ncbi.nlm.nih.gov/pubmed/19332801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901506106
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