Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal surfaces. However, most promising ARV entry inhibitors are biologicals, which are costly to manufacture and deliver to...

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Główni autorzy: O'Keefe, Barry R., Vojdani, Fakhrieh, Buffa, Viviana, Shattock, Robin J., Montefiori, David C., Bakke, James, Mirsalis, Jon, d'Andrea, Anna-Lisa, Hume, Steven D., Bratcher, Barry, Saucedo, Carrie J., McMahon, James B., Pogue, Gregory P., Palmer, Kenneth E.
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2009
Hasła przedmiotowe:
Biological Sciences
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662964/
https://ncbi.nlm.nih.gov/pubmed/19332801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901506106
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