A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND

Many G protein-coupled receptors (GPCRs) possess allosteric binding sites distinct from the orthosteric site utilized by their cognate ligands, but most GPCR allosteric modulators reported to date lack signaling efficacy in their own right. McN-A-343 (4-(N-(3-chlorophenyl)carbamoyloxy)-2-butynyltrim...

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Bibliographische Detailangaben
Hauptverfasser: Valant, Celine, Gregory, Karen J., Hall, Nathan E., Scammells, Peter J., Lew, Michael J., Sexton, Patrick M., Christopoulos, Arthur
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662018/
https://ncbi.nlm.nih.gov/pubmed/18723515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803801200
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