A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND

Many G protein-coupled receptors (GPCRs) possess allosteric binding sites distinct from the orthosteric site utilized by their cognate ligands, but most GPCR allosteric modulators reported to date lack signaling efficacy in their own right. McN-A-343 (4-(N-(3-chlorophenyl)carbamoyloxy)-2-butynyltrim...

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Autors principals: Valant, Celine, Gregory, Karen J., Hall, Nathan E., Scammells, Peter J., Lew, Michael J., Sexton, Patrick M., Christopoulos, Arthur
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662018/
https://ncbi.nlm.nih.gov/pubmed/18723515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803801200
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