A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND

Many G protein-coupled receptors (GPCRs) possess allosteric binding sites distinct from the orthosteric site utilized by their cognate ligands, but most GPCR allosteric modulators reported to date lack signaling efficacy in their own right. McN-A-343 (4-(N-(3-chlorophenyl)carbamoyloxy)-2-butynyltrim...

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Autori principali: Valant, Celine, Gregory, Karen J., Hall, Nathan E., Scammells, Peter J., Lew, Michael J., Sexton, Patrick M., Christopoulos, Arthur
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662018/
https://ncbi.nlm.nih.gov/pubmed/18723515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803801200
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