Identifying and Characterizing a Functional HIV-1 Reverse Transcriptase-binding Site on Integrase

Integrase (IN) from human immunodeficiency virus, type 1 (HIV-1) exerts pleiotropic effects in the viral replication cycle. Besides integration, IN mutations can impact nuclear import, viral maturation, and reverse transcription. IN and reverse transcriptase (RT) interact in vitro, and the IN C-term...

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Main Authors: Wilkinson, Thomas A., Januszyk, Kurt, Phillips, Martin L., Tekeste, Shewit S., Zhang, Min, Miller, Jennifer T., Le Grice, Stuart F. J., Clubb, Robert T., Chow, Samson A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658086/
https://ncbi.nlm.nih.gov/pubmed/19150986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806241200
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