Mutations M184V and Y115F in HIV-1 Reverse Transcriptase Discriminate against “Nucleotide-competing Reverse Transcriptase Inhibitors”

Indolopyridones are potent inhibitors of reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1). Although the structure of these compounds differs from established nucleoside analogue RT inhibitors (NRTIs), previous studies suggest that the prototype compound INDOPY-1 may bind...

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Detalhes bibliográficos
Main Authors: Ehteshami, Maryam, Scarth, Brian J., Tchesnokov, Egor P., Dash, Chandravanu, Le Grice, Stuart F. J., Hallenberger, Sabine, Jochmans, Dirk, Götte, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573056/
https://ncbi.nlm.nih.gov/pubmed/18728003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804882200
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