Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids

The crystal structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) bound to an RNA/DNA hybrid reveals an extensive network of contacts with the phosphate backbone of the DNA strand ∼4–9 bp downstream from the ribonuclease H (RNase H) catalytic center. Collectively design...

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Bibliographic Details
Main Authors: Dash, Chandravanu, Scarth, Brian J., Badorrek, Christopher, Götte, Matthias, Le Grice, Stuart F. J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582618/
https://ncbi.nlm.nih.gov/pubmed/18836193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn678
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