Mechanisms Associated with HIV-1 Resistance to Acyclovir by the V75I Mutation in Reverse Transcriptase

It has recently been demonstrated that the anti-herpetic drug acyclovir (ACV) also displays antiviral activity against the human immunodeficiency virus type 1 (HIV-1). The triphosphate form of ACV is accepted by HIV-1 reverse transcriptase (RT), and subsequent incorporation leads to classical chain...

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Bibliographic Details
Main Authors: Tchesnokov, Egor P., Obikhod, Aleksandr, Massud, Ivana, Lisco, Andrea, Vanpouille, Christophe, Brichacek, Beda, Balzarini, Jan, McGuigan, Christopher, Derudas, Marco, Margolis, Leonid, Schinazi, Raymond F., Götte, Matthias
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755874/
https://ncbi.nlm.nih.gov/pubmed/19509419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024026
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