The application of phosphoramidate ProTide technology to acyclovir confers anti-HIV inhibition

Recently it has been reported that phosphorylated acyclovir (ACV) inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in a cell free system. To deliver phosphorylated ACV inside cells we designed ACV monophosphorylated derivatives using ProTide technology. We found that the L-...

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Bibliographic Details
Main Authors: Derudas, Marco, Carta, Davide, Brancale, Andrea, Vanpouille, Christophe, Lisco, Andrea, Margolis, Leonid, Balzarini, Jan, McGuigan, Christopher
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748767/
https://ncbi.nlm.nih.gov/pubmed/19645484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9007856
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