Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Bioorg Med Chem
Päätekijät: Derudas, Marco, Brancale, Andrea, Naesens, Lieve, Neyts, Johan, Balzarini, Jan, McGuigan, Christopher
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier Ltd. 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125978/
https://ncbi.nlm.nih.gov/pubmed/20207546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.015
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