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Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin
Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a...
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| 出版年: | Bioorg Med Chem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier Ltd.
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125978/ https://ncbi.nlm.nih.gov/pubmed/20207546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.015 |
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