Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis and biological evaluation of new acyclic nucleoside ProTides

Following our findings on the anti-HIV activity of acyclovir phosphate prodrugs, we herein report the ProTide approach applied to a series of acyclic nucleosides aimed at the identification of novel and selective antiviral (i.e. HIV) agents. Acyclic nucleoside analogues used in this study were ident...

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Publicado en:J Med Chem
Autores principales: Derudas, Marco, Vanpouille, Christophe, Carta, Davide, Zicari, Sonia, Andrei, Graciela, Snoeck, Robert, Brancale, Andrea, Margolis, Leonid, Balzarini, Jan, McGuigan, Christopher
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731253/
https://ncbi.nlm.nih.gov/pubmed/28829913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01009
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