Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides

We report the synthesis of a series of novel 2′-deoxy-2′,2′-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2′-deoxy-2′,2′-difluoro-5-iodo- and -5-bromo-uridines showed selective a...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Quintiliani, Maurizio, Persoons, Leentje, Solaroli, Nicola, Karlsson, Anna, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, McGuigan, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: Published by Elsevier Ltd. 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127735/
https://ncbi.nlm.nih.gov/pubmed/21696963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.05.037
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