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Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin
Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a...
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| Опубликовано в: : | Bioorg Med Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier Ltd.
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125978/ https://ncbi.nlm.nih.gov/pubmed/20207546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.015 |
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