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The application of phosphoramidate ProTide technology to acyclovir confers anti-HIV inhibition
Recently it has been reported that phosphorylated acyclovir (ACV) inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in a cell free system. To deliver phosphorylated ACV inside cells we designed ACV monophosphorylated derivatives using ProTide technology. We found that the L-...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748767/ https://ncbi.nlm.nih.gov/pubmed/19645484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9007856 |
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