ACYCLOVIR IS ACTIVATED INTO A HIV-1 REVERSE TRANSCRIPTASE INHIBITOR IN HERPESVIRUS-INFECTED HUMAN TISSUES

For most viruses, including HIV, there is a need for antimicrobials that target unique viral molecular properties. Acyclovir (ACV) is such a drug for human herpesviruses (HHVs): it is activated into a HHV-DNA polymerase inhibitor exclusively by HHV-kinases and thus does not suppress other viruses. H...

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Autori principali: Lisco, Andrea, Vanpouille, Christophe, Tchesnokov, Egor P., Grivel, Jean-Charles, Biancotto, Angélique, Brichacek, Beda, Elliott, Julie, Fromentin, Emilie, Shattock, Robin, Anton, Peter, Gorelick, Robert, Balzarini, Jan, McGuigan, Christopher, Derudas, Marco, Götte, Matthias, Schinazi, Raymond F., Margolis, Leonid
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210193/
https://ncbi.nlm.nih.gov/pubmed/18779052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.07.008
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