Identifying and Characterizing a Functional HIV-1 Reverse Transcriptase-binding Site on Integrase

Integrase (IN) from human immunodeficiency virus, type 1 (HIV-1) exerts pleiotropic effects in the viral replication cycle. Besides integration, IN mutations can impact nuclear import, viral maturation, and reverse transcription. IN and reverse transcriptase (RT) interact in vitro, and the IN C-term...

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Bibliographic Details
Main Authors: Wilkinson, Thomas A., Januszyk, Kurt, Phillips, Martin L., Tekeste, Shewit S., Zhang, Min, Miller, Jennifer T., Le Grice, Stuart F. J., Clubb, Robert T., Chow, Samson A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658086/
https://ncbi.nlm.nih.gov/pubmed/19150986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806241200
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