Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor

Crystal structures of the epidermal growth factor (EGF) receptor suggest that its activation is associated with extensive conformational changes in both the extracellular and intracellular domains. However, evidence of these structural dynamics in intact cells has been lacking. Here we use luciferas...

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Bibliographic Details
Main Authors: Yang, Katherine S., Ilagan, Ma. Xenia G., Piwnica-Worms, David, Pike, Linda J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658043/
https://ncbi.nlm.nih.gov/pubmed/19171934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808041200
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