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Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor

Crystal structures of the epidermal growth factor (EGF) receptor suggest that its activation is associated with extensive conformational changes in both the extracellular and intracellular domains. However, evidence of these structural dynamics in intact cells has been lacking. Here we use luciferas...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yang, Katherine S., Ilagan, Ma. Xenia G., Piwnica-Worms, David, Pike, Linda J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658043/
https://ncbi.nlm.nih.gov/pubmed/19171934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808041200
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