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Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging
Binding of EGF to its receptor induces dimerization of the normally monomeric receptor. Activation of its intracellular tyrosine kinase then occurs through the formation of an asymmetric kinase dimer in which one subunit, termed the “receiver” kinase, is activated by interaction with the other subun...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252912/ https://ncbi.nlm.nih.gov/pubmed/22190492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111316109 |
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