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Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

Binding of EGF to its receptor induces dimerization of the normally monomeric receptor. Activation of its intracellular tyrosine kinase then occurs through the formation of an asymmetric kinase dimer in which one subunit, termed the “receiver” kinase, is activated by interaction with the other subun...

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Auteurs principaux: Macdonald-Obermann, Jennifer L., Piwnica-Worms, David, Pike, Linda J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252912/
https://ncbi.nlm.nih.gov/pubmed/22190492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111316109
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