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Allosteric regulation of epidermal growth factor (EGF) receptor ligand binding by tyrosine kinase inhibitors

The epidermal growth factor (EGF) receptor is a classical receptor tyrosine kinase with an extracellular ligand-binding domain and an intracellular kinase domain. Mutations in the EGF receptor have been shown to drive uncontrolled cell growth and are associated with a number of different tumors. Two...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Macdonald-Obermann, Jennifer L., Pike, Linda J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120208/
https://ncbi.nlm.nih.gov/pubmed/29997256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004139
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