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Different Epidermal Growth Factor (EGF) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation

The EGF receptor has seven different cognate ligands. Previous work has shown that these different ligands are capable of inducing different biological effects, even in the same cell. To begin to understand the molecular basis for this variation, we used luciferase fragment complementation to measur...

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Autores principales: Macdonald-Obermann, Jennifer L., Pike, Linda J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176247/
https://ncbi.nlm.nih.gov/pubmed/25086039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586826
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