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Different Epidermal Growth Factor (EGF) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation

The EGF receptor has seven different cognate ligands. Previous work has shown that these different ligands are capable of inducing different biological effects, even in the same cell. To begin to understand the molecular basis for this variation, we used luciferase fragment complementation to measur...

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Detalhes bibliográficos
Main Authors: Macdonald-Obermann, Jennifer L., Pike, Linda J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176247/
https://ncbi.nlm.nih.gov/pubmed/25086039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586826
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