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Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent

The EGF receptor is a classic receptor tyrosine kinase. It contains nine tyrosines in its C-terminal tail, many of which are phosphorylated and bind proteins containing SH2 or phosphotyrosine-binding (PTB) domains. To determine how many and which tyrosines are required to enable EGF receptor-mediate...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Gill, Kamaldeep, Macdonald-Obermann, Jennifer L., Pike, Linda J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733609/
https://ncbi.nlm.nih.gov/pubmed/29074618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802553
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