Asp-960/Glu-961 Controls the Movement of the C-terminal Tail of the Epidermal Growth Factor Receptor to Regulate Asymmetric Dimer Formation

The epidermal growth factor (EGF) receptor is a tyrosine kinase that dimerizes in response to ligand binding. Ligand-induced dimerization of the extracellular domain of the receptor promotes formation of an asymmetric dimer of the intracellular kinase domains, leading to stimulation of the tyrosine...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Katherine S., Macdonald-Obermann, Jennifer L., Piwnica-Worms, David, Pike, Linda J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911325/
https://ncbi.nlm.nih.gov/pubmed/20507979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103317
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