Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor

Crystal structures of the epidermal growth factor (EGF) receptor suggest that its activation is associated with extensive conformational changes in both the extracellular and intracellular domains. However, evidence of these structural dynamics in intact cells has been lacking. Here we use luciferas...

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Detaylı Bibliyografya
Asıl Yazarlar: Yang, Katherine S., Ilagan, Ma. Xenia G., Piwnica-Worms, David, Pike, Linda J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Mechanisms of Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658043/
https://ncbi.nlm.nih.gov/pubmed/19171934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808041200
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