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Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase

All cells contain specialized translesion DNA polymerases that replicate past sites of DNA damage. We find that Escherichia coli translesion DNA polymerase II (Pol II) and polymerase IV (Pol IV) function with DnaB helicase and regulate its rate of unwinding, slowing it to as little as 1 bp/s. Furthe...

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Bibliografiske detaljer
Main Authors: Indiani, Chiara, Langston, Lance D., Yurieva, Olga, Goodman, Myron F., O'Donnell, Mike
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654394/
https://ncbi.nlm.nih.gov/pubmed/19279203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901403106
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