CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

DNA replication in eukaryotes is asymmetric, with separate DNA polymerases (Pol) dedicated to bulk synthesis of the leading and lagging strands. Pol α/primase initiates primers on both strands that are extended by Pol ε on the leading strand and by Pol δ on the lagging strand. The CMG (Cdc45-MCM-GIN...

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Detalhes bibliográficos
Main Authors: Langston, Lance D., Zhang, Dan, Yurieva, Olga, Georgescu, Roxana E., Finkelstein, Jeff, Yao, Nina Y., Indiani, Chiara, O’Donnell, Mike E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217400/
https://ncbi.nlm.nih.gov/pubmed/25313033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418334111
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