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RecA acts as a switch to regulate polymerase occupancy in a moving replication fork

This report discovers a role of Escherichia coli RecA, the cellular recombinase, in directing the action of several DNA polymerases at the replication fork. Bulk chromosome replication is performed by DNA polymerase (Pol) III. However, E. coli contains translesion synthesis (TLS) Pols II, IV, and V...

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Autori principali: Indiani, Chiara, Patel, Meghna, Goodman, Myron F., O’Donnell, Mike E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619308/
https://ncbi.nlm.nih.gov/pubmed/23509251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303301110
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