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Formation and Stability of a Vinyl Carbanion at the Active Site of Orotidine 5′-Monophosphate Decarboxylase: pK(a) of the C-6 Proton of Enzyme-Bound UMP
[Image: see text] We report that orotidine 5′-monophosphate decarboxylase (OMPDC) catalyzes exchange of the C-6 proton of uridine 5′-monophosphate (UMP) for deuterium from solvent in D(2)O at 25 °C and pD 7.0 – 9.3. Kinetic analysis of deuterium exchange gives pK(a) ≤ 22 for carbon deprotonation of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652670/ https://ncbi.nlm.nih.gov/pubmed/18186641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710384t |
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