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Role of a Guanidinium Cation-Phosphodianion Pair in Stabilizing the Vinyl Carbanion Intermediate of Orotidine 5'-Phosphate Decarboxylase-Catalyzed Reactions.()

The side chain cation of Arg235 provides a 5.6 and 2.6 kcal/mol stabilization of the transition states for orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae (OMPDC) catalyzed reactions of OMP and 5-fluoroorotidine 5'-monophosphate (FOMP), respectively, a 7.2 kcal/mol s...

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Detalhes bibliográficos
Main Authors: Goryanova, Bogdana, Goldman, Lawrence M., Amyes, Tina L., Gerlt, John A, Richard, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838641/
https://ncbi.nlm.nih.gov/pubmed/24053466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401117y
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