OMP Decarboxylase: Phosphodianion Binding Energy is Used to Stabilize a Vinyl Carbanion Intermediate

Orotidine 5′-monophosphate decarboxylase (OMPDC) catalyzes the exchange for deuterium from solvent D(2)O of the C-6 proton of 1-(β-D-erythrofuranosyl)-5-fluorouracil (FEU), a phosphodianion truncated product analog. The deuterium exchange reaction of FEU is accelerated 1.8 × 10(4)-fold by 1 M phosph...

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Bibliographic Details
Main Authors: Goryanova, Bogdana, Amyes, Tina L., Gerlt, John A., Richard, John P.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099264/
https://ncbi.nlm.nih.gov/pubmed/21486036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201734z
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