Orotidine 5′-Monophosphate Decarboxylase: Transition State Stabilization from Remote Protein-Phosphodianion Interactions

Mutants of orotidine 5′-monophosphate decarboxylase containing all possible single (Q215A, Y217F, R235A), double and triple substitutions of the side chains that interact with the phosphodianion group of the substrate orotidine 5′-monophosphate have been prepared. Essentially the entire effect of th...

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Detalhes bibliográficos
Main Authors: Amyes, Tina L., Ming, Shonoi A., Goldman, Lawrence M., Wood, B. McKay, Desai, Bijoy J., Gerlt, John A., Richard, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431445/
https://ncbi.nlm.nih.gov/pubmed/22620855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300585e
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