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Mechanism of the Orotidine 5’-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

Orotidine 5’-monophosphate decarboxylase (OMPDC) is an exceptionally proficient catalyst: the rate acceleration (k(cat)/k(non)) is 7.1 × 10(16) and the proficiency [(k(cat)/K(M))/k(non)] is 4.8 × 10(22) M(−1). The structural basis for the large rate acceleration and proficiency is unknown, although...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Wood, B. McKay, Chan, Kui K., Amyes, Tina L., Richard, John P., Gerlt, John A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735758/
https://ncbi.nlm.nih.gov/pubmed/19435313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9006226
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