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An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

Closure of the active site phosphate gripper loop of orotidine 5′-monophosphate decarboxylase from Saccharomyces cerevisiae (ScOMPDC) over the bound substrate orotidine 5′-monophosphate (OMP) activates the bound substrate for decarboxylation by at least 10(4)-fold [Amyes, T. L., Richard, J. P., and...

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Detalhes bibliográficos
Main Authors: Toth, Krisztina, Amyes, Tina L., Wood, B. McKay, Chan, Kui K., Gerlt, John A., Richard, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754381/
https://ncbi.nlm.nih.gov/pubmed/19618917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901064k
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