TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis

TRF1 is a component of the shelterin complex at mammalian telomeres; however, a role for TRF1 in telomere biology in the context of the organism is unclear. In this study, we generated mice with transgenic TRF1 expression targeted to epithelial tissues (K5TRF1 mice). K5TRF1 mice have shorter telomer...

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Bibliografiske detaljer
Main Authors: Muñoz, Purificacion, Blanco, Raquel, de Carcer, Guillermo, Schoeftner, Stefan, Benetti, Roberta, Flores, Juana M., Malumbres, Marcos, Blasco, Maria A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648247/
https://ncbi.nlm.nih.gov/pubmed/19124610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01339-08
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