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Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis
TRF2 is a telomere-binding protein with roles in telomere protection and telomere-length regulation. The fact that TRF2 is up-regulated in some human tumors suggests a role of TRF2 in cancer. Mice that overexpress TRF2 in the skin, K5TRF2 mice, show critically short telomeres and are susceptible to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1770903/ https://ncbi.nlm.nih.gov/pubmed/17234886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.406207 |
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