Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease has remained elusive. Here, we report on cells and mice conditionally deleted for TRF1. TRF1-deleted mouse embryonic fibroblasts (MEFs) show ra...

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Detalhes bibliográficos
Main Authors: Martínez, Paula, Thanasoula, Maria, Muñoz, Purificación, Liao, Chunyan, Tejera, Agueda, McNees, Carolyn, Flores, Juana M., Fernández-Capetillo, Oscar, Tarsounas, Madalena, Blasco, Maria A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751970/
https://ncbi.nlm.nih.gov/pubmed/19679647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.543509
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