TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

The TPP1/ACD protein (hereafter TPP1) is a component of the shelterin complex at mammalian telomeres. Here we find that Tpp1-deficient mouse embryonic fibroblasts (MEFs) show increased chromosomal instability including sister chromatid fusions and chromosomes with multitelomeric signals related to t...

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Hauptverfasser: Tejera, Agueda M., Stagno d’Alcontres, Martina, Thanasoula, Maria, Marion, Rosa M., Martinez, Paula, Liao, Chunyan, Flores, Juana M., Tarsounas, Madalena, Blasco, Maria A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631760/
https://ncbi.nlm.nih.gov/pubmed/20493811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.03.011
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