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TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis
TRF1 is a component of the shelterin complex at mammalian telomeres; however, a role for TRF1 in telomere biology in the context of the organism is unclear. In this study, we generated mice with transgenic TRF1 expression targeted to epithelial tissues (K5TRF1 mice). K5TRF1 mice have shorter telomer...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648247/ https://ncbi.nlm.nih.gov/pubmed/19124610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01339-08 |
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