Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

Telomeres are heterochromatic structures at chromosome ends essential for chromosomal stability. Telomere shortening and the accumulation of dysfunctional telomeres are associated with organismal aging. Using telomerase-deficient TRF2-overexpressing mice (K5TRF2/Terc(−/−)) as a model for accelerated...

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Bibliografski detalji
Glavni autori: Schoeftner, Stefan, Blanco, Raquel, de Silanes, Isabel Lopez, Muñoz, Purificación, Gómez-López, Gonzalo, Flores, Juana M., Blasco, Maria A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772818/
https://ncbi.nlm.nih.gov/pubmed/19887628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909265106
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