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Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations
Telomeres are heterochromatic structures at chromosome ends essential for chromosomal stability. Telomere shortening and the accumulation of dysfunctional telomeres are associated with organismal aging. Using telomerase-deficient TRF2-overexpressing mice (K5TRF2/Terc(−/−)) as a model for accelerated...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772818/ https://ncbi.nlm.nih.gov/pubmed/19887628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909265106 |
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