Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

Telomeres are heterochromatic structures at chromosome ends essential for chromosomal stability. Telomere shortening and the accumulation of dysfunctional telomeres are associated with organismal aging. Using telomerase-deficient TRF2-overexpressing mice (K5TRF2/Terc(−/−)) as a model for accelerated...

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Bibliographic Details
Main Authors: Schoeftner, Stefan, Blanco, Raquel, de Silanes, Isabel Lopez, Muñoz, Purificación, Gómez-López, Gonzalo, Flores, Juana M., Blasco, Maria A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772818/
https://ncbi.nlm.nih.gov/pubmed/19887628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909265106
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