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Essential role for the TRF2 telomere protein in adult skin homeostasis
TRF2 is a component of shelterin, the protein complex that protects the ends of mammalian chromosomes. TRF2 is essential for telomere capping owing to its roles in suppressing an ATM-dependent DNA damage response (DDR) at chromosome ends and inhibiting end-to-end chromosome fusions. Mice deficient f...
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| Publicado no: | Aging Cell |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4326939/ https://ncbi.nlm.nih.gov/pubmed/24725274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12221 |
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