The mTOR pathway is necessary for survival of mice with short telomeres

Telomerase deficiency leads to age-related diseases and shorter lifespans. Inhibition of the mechanistic target of rapamycin (mTOR) delays aging and age-related pathologies. Here, we show that telomerase deficient mice with short telomeres (G2-Terc(−/−)) have an hyper-activated mTOR pathway with inc...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ferrara-Romeo, Iole, Martinez, Paula, Saraswati, Sarita, Whittemore, Kurt, Graña-Castro, Osvaldo, Thelma Poluha, Lydia, Serrano, Rosa, Hernandez-Encinas, Elena, Blanco-Aparicio, Carmen, Maria Flores, Juana, Blasco, Maria A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054554/
https://ncbi.nlm.nih.gov/pubmed/32127537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14962-1
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