Tau Aggregation in Alzheimer's Disease: What Role for Phosphorylation?

The crucial role of the neuronal Tau protein in microtubule stabilization and axonal transport suggests that too little or too much Tau might lead to neuronal dysfunction. The presence of a hyper phosphorylated but non aggregated molecule as a toxic species that might sequester normal Tau is discuss...

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Autors principals: Lippens, Guy, Sillen, Alain, Landrieu, Isabelle, Amniai, Laziza, Sibille, Nathalie, Barbier, Pascale, Leroy, Arnaud, Hanoulle, Xavier, Wieruszeski, Jean-Michel
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2007
Matèries:
Mini-Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633703/
https://ncbi.nlm.nih.gov/pubmed/19164903
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