Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy

[Image: see text] Cyclosporine A (CsA) and its chemical analogues EthVal4Cs, MeVal4Cs, and Me(d-Ala)3EthVal4Cs (Alisporivir) all interact with cyclophilin A (CypA). The latter Alisporivir is a nonimmunosuppressive CsA derivative that has potent anti-HCV properties in clinical trials. We show here th...

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Bibliographic Details
Main Authors: Landrieu, Isabelle, Hanoulle, Xavier, Fritzinger, Bernd, Horvath, Dragos, Wieruszeski, Jean-Michel, Lippens, Guy
Format: Artigo
Language:Inglês
Published: American Chemical Society 2011
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018068/
https://ncbi.nlm.nih.gov/pubmed/24900335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200039u
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