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Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy
[Image: see text] Cyclosporine A (CsA) and its chemical analogues EthVal4Cs, MeVal4Cs, and Me(d-Ala)3EthVal4Cs (Alisporivir) all interact with cyclophilin A (CypA). The latter Alisporivir is a nonimmunosuppressive CsA derivative that has potent anti-HCV properties in clinical trials. We show here th...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical Society
2011
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018068/ https://ncbi.nlm.nih.gov/pubmed/24900335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200039u |
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