Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

Nonstructural protein 5A (NS5A) is essential for hepatitis C virus (HCV) replication and constitutes an attractive target for antiviral drug development. Although structural data for its in-plane membrane anchor and domain D1 are available, the structure of domains 2 (D2) and 3 (D3) remain poorly de...

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Autores principales: Verdegem, Dries, Badillo, Aurélie, Wieruszeski, Jean-Michel, Landrieu, Isabelle, Leroy, Arnaud, Bartenschlager, Ralf, Penin, François, Lippens, Guy, Hanoulle, Xavier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121464/
https://ncbi.nlm.nih.gov/pubmed/21489988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182436
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