NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B

Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication of the hepatitis C virus (HCV) RNA genome and therefore is central for its life cycle. NS5B interacts with the intrinsically disordered domain 2 of NS5A (NS5A-D2), another essential multifunctional HCV pr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bessa, Luiza M., Launay, Hélène, Dujardin, Marie, Cantrelle, François-Xavier, Lippens, Guy, Landrieu, Isabelle, Schneider, Robert, Hanoulle, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672029/
https://ncbi.nlm.nih.gov/pubmed/28912275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813766
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