NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B

Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication of the hepatitis C virus (HCV) RNA genome and therefore is central for its life cycle. NS5B interacts with the intrinsically disordered domain 2 of NS5A (NS5A-D2), another essential multifunctional HCV pr...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Bessa, Luiza M., Launay, Hélène, Dujardin, Marie, Cantrelle, François-Xavier, Lippens, Guy, Landrieu, Isabelle, Schneider, Robert, Hanoulle, Xavier
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672029/
https://ncbi.nlm.nih.gov/pubmed/28912275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813766
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki